Hypofractionated Radiosurgery Re-irradiation in Nasopharyngeal Recurrence after Complex Treatment
Author(s):
Lena Marinova, Vaska Vasileva, Nikolay Kahchiev and Katia Sergieva
The clinical case presented by us with locally advanced T4 nasopharyngeal carcinoma with intracranial infiltration and extensive parapharyngeal spread, despite intensity modulated radiotherapy (IMRT) up to 70 Gy, developed an inoperable local recurrence after two years.
Our goal is to track the radiobiological changes in the area of re-irradiation, which are evident both clinically and pathohistologically from biopsies after radiosurgery and from imaging studies/with and without contrast CT and PET/CT.
The conclusion is that the extremely high radiosensitivity of nasopharyngeal carcinoma requires a strict individual assessment of the dose delivered by hypofractionated radiosurgery. It is of great importance to respect the constraints of all nearby normal structures.