Medical & Clinical Research

Author(s): Cesarone MR, Hu S, Scipione V , Scipione C , Belcaro G, Bombardelli E, Cox D, Cotellese R and Feragalli B

This review presents results from recent supplement studies on PhytoRelief, an oral product including standardized natural extracts of pomegranate, curcuma and ginger. PhytoRelief (PF) lozenges dissolve slowly in the mouth producing a protective mucosal gel/film acting as a barrier against the most common upper respiratory tract (URT) viral infection. GLOBAL EVALUATION: PR (as a pharma-standard supplement) appears to be effective – according to recent, controlled and prospective registry studies - as a virucidal (on Covid-19) and a germicidal (bactericidal) product – but more clinical studies in patients with different conditions are needed. Clinically, PR helps preventing a number of episodes of cold and flu and limits symptoms and the duration of the URT problem. This OTC product can be used without prescription – without risks of side effects - and it appears to be generally effective on most signs and symptoms of viral infections. PR has a good preventive value. No side effects or tolerability problem were observed in any patient. The important virucidal and germicidal activities to be better defined need larger and a more prolonged evaluation period in different contexts associated to viral infections. With predictive analytics and careful planning, it is possible to show the virucidal-bactericidal effects (and their clinical preventive efficacy) of PR in weeks. The planning of new studies – also evaluating the effects of PR on the immune system - is in progress.